Karolinska Cardiorenal Theme-centre and StockholmHeartbank (KKT)

Danderyd Hospital

Status: Unknown

Conditions: Chronic Kidney Disease; Ischemic Heart Disease; Acute Coronary Syndrome; Chronic Renal Failure; Myocardial Infarction

Study type: Observational

Funder types: Other

Identifiers

NCT01204645

KKT

Details and patient eligibility

About

Chronic kidney disease (CKD) affects 10-18% of the adult population and is becoming recognized as one of the most serious disorders causing increased risk for cardiovascular disease and death. In patients with ischemic heart disease 26% have increased creatinine, which rises to 40% if patients also have diabetes mellitus. Risk increases as renal function diminishes, and just slowing the rate of decline in renal function would have a tremendous impact on health and morbidity. This association is commonly termed the Cardiorenal Syndrome, though it is caused by a much more complex interplay between major pathogenetic pathways such as glucose metabolism and diabetes, systemic and tissue inflammation, tissue metabolism, coagulation, mineral metabolism, sympathetic activation, renin-angiotensin-aldosterone system activation, endothelial dysfunction, lipid metabolism, fetal programming etc.

Karolinska Institutet recently merged basic and clinical researchers in all these fields, creating a Karolinska Kardiorenal Theme Centre; ultimately aiming to explore the syndrome and provide improved care for the individual patient.

The investigators road to success:

• Creating a Biobank (blood, DNA, plasma) from the majority of all hosptalized patients with ACS in Stockholm county - Stockholmheartbank.
• This Theme Center include all teaching hospitals associated with Karolinska Institutet; Danderyd University Hospital, Karolinska University Hospital and Södersjukhuset University Hospital. Together theses hospitals serve as emergency hospitals for 1.9 million people. The investigators are aiming at creating a biobank from all patients admitted for an acute coronary event (about 2.300/yr), which is a unique asset for molecular and genetic research as well as observational and intervention studies.
• The investigators have access to the National registry with 100% coverage, that contains data on all patients admitted to Stockholms coronary care units since 1995.
• To ensure translation in to clinical practice, most of the researchers are also MD:s, and several are clinically active.
• The clinical network facilitates the development of novel therapies and translational research.
• Steering groups for Education and a Clinical Practice implementation program.

Enrollment: 10,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients admitted to one of the four major emergency hospitals in Stockholm, for an acute coronary event.
• All patients admitted to one of the four major emergency hospitals in Stockholm, for an elective coronary angiography

Exclusion criteria

• Severe hemodynamic instability with the need of inotropic therapy and at the same time anemia with haemoglobin <1.1 g/dL

Trial design

10,000 participants in 3 patient groups

Acute Coronary Syndrome (ACS)

Description:

Continuous inclusion at emergency hospitals of patients with acute coronary syndrome (according to ESC/AHA definitions)

Follow up

Description:

Patients included at 6 or 12 months follow-up visit after an acute coronary event.

Coronary

Description:

Patients included when undergoing an coronary angiography for suspected or confirmed coronary heart disease