KDIGO Bundle to Prevent AKI in Sepsis

Hospital General Universitario Elche

Status

Unknown

Conditions

Septic Acute Kidney Injury

Treatments

Procedure: Preventive recommendations for kidney disease: guidelines for improving overall outcomes (KDIGO) for AKI

Study type

Interventional

Funder types

Other

Identifiers

NCT04222361

PI 42/2018

Details and patient eligibility

About

Summary: Controlled, prospective, randomized and randomized clinical trial of two intervention groups (standard care vs. preventive recommendations the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for AKI) of patients diagnosed with sepsis and abdominal post-surgical septic shock with positive results in the risk determination of acute renal injury by NephroCheck® Test that integrates the urinary biomarkers TIMP-2 and IGFBP-7.

Hypothesis: The implementation of a package of preventive measures proposed by the KDIGO guide can reduce the occurrence and severity of acute renal injury in the high-risk abdominal post-surgical septic patient detected by urinary biomarkers for early detection.

Enrollment

100 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients older than 18 years.
Patients (or their informed family members) who accept and sign the informed consent.
Patients diagnosed with sepsis or abdominal post-surgical septic shock.

Exclusion criteria

Patients under 18 years.
Patients (or their authorized relatives) who refuse to sign the informed consent.
Patients diagnosed with sepsis or non-surgical septic shock.
Patients diagnosed with sepsis or septic shock of origin other than abdominal.
Patients with AKI stages KDIGO 2 and 3 and / or renal replacement therapy.
Patients with chronic renal failure and glomerular filtration <30 ml / min and / or undergoing treatment with dialysis or previous renal transplantation.
Patients with AKI of origin other than the diagnosed septic, such as glomerulonephritis or interstitial nephritis, renal artery occlusion and / or postrenal obstruction.