Kefir on Bone Mineral Density and Bone Metabolism in Osteoporotic Patients

Ministry of Science and Technology, Taiwan

Status: Completed

Conditions: Osteoporosis

Treatments: Other: Kefir; Other: Placebo; Other: CaCO3

Study type: Interventional

Funder types: Other

Identifiers

NCT02361372

NSC-99-2324-B-005-017-CC1

Details and patient eligibility

About

In a controlled, parallel, double-blind intervention study over 6 months, the investigators investigated the effects of kefir-fermented milk (1,600 mg/kg) supplemented with calcium bicarbonate (CaCO3, 1,500 mg/kg) and bone metabolism in 40 osteoporosis patients, and compared them with CaCO3 alone without kefir supplements. Bone turnover markers were measured in fasting blood samples collected before therapy and at 1, 3, and 6 months. BMD values at the spine, total hip, and hip femoral neck were assessed by dual-energy x-ray absorptiometry (DXA) at baseline and at 6 months.

Enrollment: 69 patients

Sex: All

Ages: 55 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of osteoporosis patients

Exclusion criteria

• Any previous use of parathyroid hormone or sodium fluoride, use of anabolic steroids or growth hormone within 6 months before trial entry or oral or intravenous systemic corticosteroids within 12 months, and any previous use of strontium.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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69 participants in 2 patient groups, including a placebo group

Kefir and CaCO3

Experimental group

Description:

Kefir were administered 1,600 mg kefir-fermented milk per day and an accompanying supplement of 1,500 mg CaCO3 for 6 months

Treatment:

Other: Kefir

Placebo and CaCO3

Placebo Comparator group

Description:

Placebo and 1,500 mg of CaCO3 daily for 6 months

Treatment:

Other: Placebo

Other: CaCO3