KERatoconus and Metalloproteinases InvesTigation (KERMIT)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: Keratoconus

Treatments: Other: immuno-histo-chemical analysis

Study type: Observational

Funder types: NETWORK

Identifiers

NCT02891655

EGN_2016_6

Details and patient eligibility

About

Corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of MMP at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and Galectin-3 by epithelial cells. A differential expression of EMMPRIN, Galectin-3 and metalloproteinases (MMP) may be observed between the apex of the keratoconus and the peripheral cornea. Highlighting the implication of EMMPRIN and Galectin-3 could lead to the development of specific inhibitors to slow or to stop keratoconus evolution.

Enrollment: 23 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 years old
• Patient with keratoconus undergoing corneal collagen cross-linking (epithelium-off methods)
• Patient with keratoconus undergoing his first corneal graft for optical indication (control)

Exclusion criteria

• Patient with keratoconus undergoing corneal graft for tectonic indication
• Patient undergoing corneal refractive surgery (refractive photokeratectomy) with a normal topography, a normal slit lamp examination and no previous ophthalmic condition (control)
• pregnant or breast feeding patient
• patient under judiciary protection
• patient opposition to participate in the study

Trial design

23 participants in 2 patient groups

surgery for keratoconus

Treatment:

Other: immuno-histo-chemical analysis

refractive surgery (control patients)

Treatment:

Other: immuno-histo-chemical analysis