Ketamine and Postoperative Depressive Symptom-PASSION

Capital Medical University

Status and phase

Completed

Phase 3

Phase 2

Conditions

Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period

Treatments

Drug: Normal saline

Drug: Ketamine

Study type

Interventional

Funder types

Other

Identifiers

NCT03086148

2017-03-16

Details and patient eligibility

About

Perioperative depression symptom (PDS) is one of the common mental comorbidity, and influences the clinical outcomes and prognosis. However, there is no rapid acting treatment to deal with it during the limited hospital stay. This study aims to determine whether ketamine could improve the depressive symptom of peirioperative patients. It will also examine the safety for administrating ketamine as an antidepressant intraoperatively. Meanwhile, it will show if ketamine could improve anxiety, postoperative pain or delirium. This trial also will bring great concerns on patients with perioperative mental health and explore the measures to improve their psycho-related prognosis.

Enrollment

84 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Brain tumor located supratentorial area and need to receive elective craniotomy;
Moderate to severe depressive symptom measured by the qualified psychiatric doctors.
Ages between 18 and 65 years old.
American Society of Anesthesiologists physical status I-III

Exclusion criteria

History of epilepsy;
Major depression disorder patients undergoing antidepressive therapy within 2 weeks; 3 Psychiatric illness; 4 Drug abuse; 5 History of allergy to the research drug; 6 Tumor located in the Wernick area, Broca area or the frontal pole; 7 Hyperthyroidism; 8 Patients can not cooperate with investigators on psychiatric assessments; 9 Pregnant or breast-feeding woman; 10 refuse to sign inform consent.