Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)

University of Wisconsin (UW)

Status and phase

Suspended

Early Phase 1

Conditions

Posttraumatic Stress Disorder

Treatments

Device: SmartSleep EEG recording headband

Drug: Ketamine

Study type

Interventional

Funder types

Other

Identifiers

NCT06378528

A538900 (Other Identifier)

2023-1706

Protocol Version 11/14/25 (Other Identifier)

Details and patient eligibility

About

The objectives of this study are to investigate the feasibility, tolerability, and preliminary efficacy of repeated ketamine-assisted psychotherapy sessions in adolescents with severe posttraumatic stress disorder. The study will enroll adolescents with a current diagnosis of posttraumatic stress disorder (PTSD) to complete three intravenous ketamine administrations accompanied by a psychotherapy session over the span of six weeks. All participants will complete an initial set of preparatory sessions, and each dosing session will be followed by three to six hours of integration sessions. Finally, participants will complete 7 nights of at-home sleep recordings. The investigators hypothesize that this protocol will be well-tolerated by adolescents and that patients will experience decreases in PTSD symptom severity at follow-up.

Full description

Primary Objective:

Characterize safety and adverse events associated with repeated ketamine-assisted psychotherapy in adolescents with PTSD.

Secondary Objectives:

Evaluate initial feasibility of recruitment and retention of adolescents with PTSD.
Explore potential impacts of ketamine-assisted psychotherapy on PTSD symptom severity at follow-up

Enrollment

5 estimated patients

Sex

All

Ages

15 to 17 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged 15-17 years old, inclusive
At baseline, meet threshold for Diagnostic and Statistical Manual (DSM-5) criteria for current PTSD as determined by the CAPS-CA.
Medically and neurologically healthy on the basis of physical examination, medical history, and the clinical judgement of the evaluating study medical provider
Must agree to inform the investigators within 48 hours of any emergent medical conditions and procedures
If of childbearing potential, must have a negative pregnancy test at study entry and prior to each KAP dosing session, and must agree to use adequate birth control through 10 days after the last KAP dosing session.
Must agree not to participate in any other interventional clinical trials during the duration of the study
Must be willing to comply with all study procedures
A primary parent or guardian is willing to provide informed consent
Are fluent in or predominantly speaking and reading in English

Exclusion criteria

Caregiver or adolescent is unwilling or unable to give adequate informed consent
Are likely, in the investigator's opinion and via observation during the Preparatory Period, to be re-exposed to their index trauma or other significant trauma, lack social support, or lack a stable living situation during study participation.
Any finding(s), based on the screening process, that the PI feels would make the study unsuitable for the participant.
Current diagnosis of or history of a psychotic disorder, bipolar disorder, or autism spectrum disorder diagnosed by the Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS) interview and clinician judgement. No other co-morbid disorders are exclusionary.
Intellectual disability (IQ<70) per medical history
History of moderate to severe substance use disorder, as determined by the KSADS and/or clinician judgement (excluding tobacco), or active substance use (including current alcohol use or positive urine toxicology)
Any prior exposure to sub-anesthetic doses of ketamine (including prior research or clinical psychiatric treatment with ketamine and/or recreational use)
Any participant presenting current serious suicide risk, as determined through the KSADS, responses to Columbia Suicide Severity Rating Scale (C-SSRS), and/or clinical judgment of the investigator, will be excluded; however, history of suicide attempts prior to enrollment is not an exclusion.
Would present a serious risk to others as established through clinical interview and contact with treating physician.
Current use benzodiazepines, opiates, or lamotrigine, which are hypothesized to interfere with ketamine's mechanism of action
High blood pressure (BP) at the time of screening, defined by the Centers for Disease Control and Prevention (CDC) to be BP greater than 130/80.
Persons who have previously received ketamine therapeutically or taken it recreationally.
Are pregnant, nursing, or are able to become pregnant and are not practicing an effective means of birth control.
Persons who are known to have a hypersensitivity to ketamine
Participants that are deemed not to be medically and neurologically healthy on the basis of physical examination, medical history, and the clinical judgement of the Study Medical Provider or qualified designee in order to participate.
- Examples of medical rule-outs include but are not limited to: unstable hypertension, recent severe neurologic injury, a history or current signs/symptoms of liver or renal insufficiency, and current diagnoses of cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, or metabolic disorders that are deemed clinically significant based on investigator judgement.