Ketamine Associated With Morphine PCA After Total Hip Arthroplasty (KETAMINE)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Arthroplasty, Replacement, Hip

Treatments: Drug: Postoperative PCA of Ketamine and morphine; Drug: Morphine; Drug: Ketamine-Morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT00797264

P060402

Details and patient eligibility

About

Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect.

We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.

Full description

Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• total hip arthroplasty

Exclusion criteria

• pre operative opioid administration

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

18 participants in 3 patient groups

A

Experimental group

Description:

Ketamine pre and per operative, and morphine postoperative

Treatment:

Drug: Ketamine-Morphine

B

Active Comparator group

Description:

NaCl pre and per operative, and morphine postoperative

Treatment:

Drug: Morphine

C

Experimental group

Description:

Ketamine and morphine postoperative

Treatment:

Drug: Postoperative PCA of Ketamine and morphine