Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Mahidol University

Status and phase: Completed; Phase 4

Conditions: Postoperative Period; Pain

Treatments: Other: NSS; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT02570230

SI2558

Details and patient eligibility

About

Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.

Enrollment: 32 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status 1-3
• elective thoracotomy
• can operate patient-controlled analgesia (PCA) machine

Exclusion criteria

patient with history of

• allergy to morphine or ketamine
• contraindicate to ketamine
• remain intubated in the postoperative period

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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32 participants in 2 patient groups, including a placebo group

Control

Placebo Comparator group

Description:

NSS infusion

Treatment:

Other: NSS

Ketamine

Experimental group

Description:

Ketamine 0.2 mg/kg/hr intravenous infusion

Treatment:

Drug: Ketamine