Ketamine Compared to Propofol for Pediatric GI Endoscopy

State University of New York - Upstate Medical University

Status: Completed

Conditions: Endoscopy

Treatments: Drug: Ketamine; Drug: Propofol

Study type: Observational

Funder types: Other

Identifiers

NCT00614159

5545UMU

Details and patient eligibility

About

Elective outpatient endoscopy for children can be safely performed under general anesthesia with either propofol (1) or ketamine (2) infusions. Both infusions have an advantage over general anesthesia with volatile agents because they do not require intubation. The goal of both infusions is to have the patient breath spontaneously without reacting to the endoscopy which is a noxious stimulus. Patient movement, stridor and vomiting are can interrupt the procedure and increase overall OR time. Propofol also carries the added risk of causing apnea. This side effect is not commonly seen with Ketamine. Our hypothesis is that Ketamine's profile makes it a superior drug to Propofol for elective outpatient endoscopy because of reduced profound intra-operative interruptions and faster recovery time. We plan a study of pediatric patients ages 1 to 10 years old undergoing elective outpatient endoscopy. The patients will be randomized to receiving either a Ketamine or Propofol infusion, and the intra-operative interruptions will be documented by the anesthesiologist. The Post Anesthetic Care Unit (PACU) time to recovery will be monitored and recorded by a third party.

Enrollment: 34 estimated patients

Sex: All

Ages: 1 to 10 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 1-10
• Endoscopy with sedation scheduled

Exclusion criteria

• A history of chronic respiratory disease
• Upper respiratory infection
• Developmental delays
• Dysrhythmias
• Increased intercranial pressure
• Any sedatives or narcotics up to 6 weeks prior to procedure.

Trial design

34 participants in 1 patient group

GI Endoscopy

Treatment:

Drug: Ketamine

Drug: Propofol