Ketamine Effects as Preemptive Analgesia

Universitas Padjadjaran

Status and phase: Completed; Phase 3; Phase 2

Conditions: Pain, Postoperative

Treatments: Other: Placebo; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT06040060

AN-202309.02

Details and patient eligibility

About

The goal of this randomized controlled trial is to compare the effect of preemptive ketamine administration to placebo administration in patients underwent hysterectomy surgery. The main questions it aims to answer are:

1. To determine the effect of ketamine at a dose of 0.5 mg/kgBW as preemptive analgesia on the duration of analgesia after hysterectomy surgery
2. To determine the effect of ketamine at a dose of 0.5 mg/kgBW as preemptive analgesia on the need for fentanyl after hysterectomy surgery

Enrollment: 40 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients aged 18-50 years.
2. ASA I and II physical status (American Society of Anesthesiologists).

Exclusion criteria

1. The patient is not willing to be included as a research subject
2. The patient takes anti-pain medication before surgery
3. History of allergies to the drugs to be used
4. History of chronic pain

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

Preemptive Ketamine

Active Comparator group

Description:

Preemptive administration of Ketamine 0.5 mg/kgBB intravenously, given 10 minutes prior to incision

Treatment:

Drug: Ketamine

Placebo

Placebo Comparator group

Description:

Placebo administration of 10 mL NaCl 0,9% intravenously, given 10 minutes prior to incision

Treatment:

Other: Placebo