Ketamine for Analgesia After Cesarean Section

Mongi Slim Hospital

Status: Completed

Conditions: Postoperative Pain; Cesarean Section

Treatments: Drug: 0.25 mg/kg of Ketamine; Drug: 20ml of normal saline solution

Study type: Interventional

Funder types: Other

Identifiers

NCT04545801

ketamine cesarean

Details and patient eligibility

About

In this prospective randomized trial, investigators compared the analgesic effect of subanesthetic dose of ketamine versus placebo in parturients undergoing cesarean section under spinal anesthesia.

Full description

In this prospective randomized trial, investigators compared the analgesic effect of subanesthetic dose of ketamine versus placebo in parturients undergoing cesarean section under spinal anesthesia.

The patients were randomized in two groups:

• Group Ketamine: these patients recieved 0.25 mg/kg of Ketamin intravenously 5 minutes after the spinal anesthesia.
• Group Placebo: recieved 20 ml of normal saline solution intravenously 5 minutes after the spinal puncture.

The investigators recorded intra demographic, intraoperative and post operative data.

The main outcome was the analgesic score: the visual analog scale (VAS). dynamic VAS was also monitored at 24 hours post operatively.

Enrollment: 80 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• full term pregnant adult patients
• Monofetal pregnancy
• scheduled for urgent or elective cesarean section under spinal anesthesia

Exclusion criteria

• necessity of general anesthesia during the procedure
• Post partum hemorrage

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups, including a placebo group

Ketamine Group

Active Comparator group

Description:

Patients recieving 0.25 mg/kg of ketamine 5 minutes after spinal anesthesia

Treatment:

Drug: 0.25 mg/kg of Ketamine

Placebo Group

Placebo Comparator group

Treatment:

Drug: 20ml of normal saline solution