Ketamine Prevent POCD (KPPOCD)
Status
Unknown
Conditions
Necrosis of Femoral Head
Knee Osteoarthritis
Treatments
Drug: Ketamine
Details and patient eligibility
About
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent. In present study investigators hypothesized that low dose ketamine would prevent the cognition decline after orthopedic surgery in aged patients.
Enrollment
484 estimated patients
Sex
All
Ages
60+ years old
Volunteers
No Healthy Volunteers
Inclusion criteria
- Elder than 60
- Easily communicated with Chinese
- Selected to kneel or hip replacement
- Agree to take part into this clinical trail
Exclusion criteria
- Existing cerebral disease， or have a history of neurological and psychiatric disease including AD, stroke and psychosis
- Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- Several audition or vision disorder
- Preoperative systolic Blood pressure over 190mmHg or diastolic pressure >100mmHg
- Existing a history of hyperthyroidism
- Patient with glaucoma
- Unwillingness to comply with the protocol or procedures
Trial design
Primary purpose
Prevention
Allocation
Randomized
Interventional model
Parallel Assignment
Masking
Quadruple Blind
484 participants in 2 patient groups, including a placebo group
Ketamine
Experimental group
Description:
Ketamine infusion group
Treatment:
Drug: Ketamine
Placebo
Placebo Comparator group
Description:
Normal saline infusion
Trial contacts and locations
3
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Data sourced from clinicaltrials.gov
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