Ketamine- Propofol Versus Pethidine- Propofol in ERCP

Assiut University

Status and phase: Completed; Phase 2

Conditions: Sedation in ERCP

Treatments: Drug: ketamine- propofol; Drug: pethidine- propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02651792

ketfol versus pethidine

Details and patient eligibility

About

The investigators aim to investigate the differences between ketamine propofol and pethidine propofol during ERCP in respect to endoscopist satisfaction.

Full description

The investigators aim to investigate the differences between ketamine propofol and pethidine propofol during ERCP in respect to endoscopist satisfaction, amount of propofol consumption Any desaturation or apnea will be recorded when the oxygen saturation (SpO2) dropped to <90% , time for recovery ,post-operative nausea and vomiting, hallucinations and Ramsey sedation scores of all patients will be recorded perioperatively. The Aldrete score was used to measure recovery from anesthesia at 5 and 10 min after the procedure.

Enrollment: 50 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• both gender
• age between 18-70

Exclusion criteria

• pregnant patients.
• morbid obesity.
• chronic obstructive pulmonary disease.
• complicated airway.
• American society of anesthesia (ASA) physical classification IV-V.
• history of allergy or contraindications to the drugs used in the study
• emergency need for ERCP.
• those whose informed consent could not be signed.
• those with possible complex ERCP.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups

ketamine- propofol

Active Comparator group

Description:

IV Ketamine 1mg/kg + Propofol 1.2 mg/kg will be given for sedation.

Treatment:

Drug: ketamine- propofol

pethidine- propofol

Active Comparator group

Description:

1.1 mg x kg(-1) pethidine + 1.2 mg x kg(-1) propofol for sedation induction

Treatment:

Drug: pethidine- propofol