Ketamine Versus Dexmedetomidine With Local Anesthetic in TAP Block

Assiut University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Lower Abdominal Cancer; Postoperative Analgesia

Treatments: Drug: control group; Drug: dexmedetomidine; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT03060070

321

Details and patient eligibility

About

Comparing the analgesic effects of ketamine and dexmedetomidine when added to local anesthetic in TAP block for postoperative analgesia after lower abdominal cancer surgery.

Enrollment: 90 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients ASA I and II to whom abdominal surgery for cancer will be conducted will be included in the study

Exclusion criteria

• Coagulopathies
• ASA III or IV, patient refusal, sensitivity to the used drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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90 participants in 3 patient groups, including a placebo group

control group,

Placebo Comparator group

Description:

saline in the same volume will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery

Treatment:

Drug: dexmedetomidine

Drug: Ketamine

ketamine group,

Active Comparator group

Description:

ketamine in a dose of 0.5mg/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery

Treatment:

Drug: control group

Drug: dexmedetomidine

dexmedetomidine group

Active Comparator group

Description:

dexmedetomidine in a dose of 1ug/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery

Treatment:

Drug: control group

Drug: Ketamine