Ketamine Versus Lidocaine Nebulization for Awake Fiberoptic Intubation

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Anesthesia

Treatments: Drug: Lidocaine; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT03414879

FMASU R3/2018

Details and patient eligibility

About

This randomized double-blinded study is performed to compare ketamine versus lidocaine for nebulization for awake nasal fiberoptic intubation as regard efficacy and side effects.

Full description

Difficult airway is one of the major challenges facing anesthesiologists. This challenge is compounded when the patient is treated while awake. The additional burden is to complete this procedure comfortably thus ensuring patient cooperation which is a vital part of successful performance. Several methods have been tried in literature to facilitate awake intubation by fiberoptic bronchoscope (FOB)

This randomized double-blinded study is performed to compare ketamine versus lidocaine for nebulization for awake nasal fiberoptic intubation as regard efficacy and side effects.

Enrollment: 60 patients

Sex: All

Ages: 21 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status I and II of both sexes with body weight from 60-90 kg, and planned for elective awake nasal fiberoptic intubation due to expected difficulty in airway management (e.g. limited mouth opening, trismus, mandibular/ maxillary swellings or tumors, ludwig's angina, or other indications).

Exclusion criteria

• body weight < 60 kg or > 90 kg
• uncooperative, with mental or psychological problems
• known allergy to any of the study drugs
• pregnancy
• hypertension
• cardiac disease
• liver or renal impairment
• epilepsy,
• asthmatic,
• previous bad experience of awake intubation,
• emergency operations or
• coagulation abnormalities

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Ketamine group

Active Comparator group

Description:

Nebulization with ketamine

Treatment:

Drug: Ketamine

Lidocaine group

Active Comparator group

Description:

Nebulization with with lidocaine

Treatment:

Drug: Lidocaine