Ketamine Versus Propofol as ICU Sedation

Menoufia University

Status and phase: Completed; Phase 4

Conditions: Propofol; Ketamine; Sedation; Mechanical Ventilation

Treatments: Drug: Ketamine; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT06243822

1/2023ANET9

Details and patient eligibility

About

this study is to assess the hemodynamic profile of ketamine compared with propofol in critically ill, mechanically ventilated adult Patients study will be carried out on 100 mechanically ventilated patients who received one sedative agent propofol or ketamine The patients will be randomized into two equal groups to receive either ketamine or propofol Group 1 (Ketamine group): ketamine is initiated at 0.5 mg/kg/h and titrated by 0.25 mg/kg/h every 15 minutes to a maximum dosage of 4 mg/kg/h to achieve appropriate sedation. Group 2 (Propofol group): Propofol is initiated at 0.3 to 0.6 mg /kg/hr. and titrated by 0.3 to 0.6 mg/kg/h every 5 to 10 minutes up to a maximum dosage of 4.5 to 4.8 mg/kg/hr. to achieve appropriate sedation.

Enrollment: 100 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• mechanically ventilated, and receive sedation with continuous infusion propofol, or ketamine for at least 24 hours

Exclusion criteria

• Receiving propofol or ketamine concurrently.

  • Transferred from an outside hospital on sedation.
  • Receiving ketamine for an indication other than sedation.
  • Daily intake of opioids.
  • Contraindication to any drug used in the study.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

Ketamine group

Active Comparator group

Treatment:

Drug: Ketamine

propofol group

Active Comparator group

Treatment:

Drug: Propofol