Ketamine vs Ephedrine on Post Spinal Hypotension in Caesarean Delivery

Ain Shams University

Status and phase: Completed; Phase 1

Conditions: Post Spinal Hypotension

Treatments: Drug: Ketalar; Drug: Ephedrine

Study type: Interventional

Funder types: Other

Identifiers

NCT07034911

FMASU MS130/2024

Details and patient eligibility

About

Comparing ketamine and ephedrine to decrease the incidence of post spinal hypotension after caesarean section delivery.

Full description

To compare the effect of ketamine versus ephedrine in decreasing the incidence of hypotension in caesarean section delivery a study group including 50 participants will receive ketamine and 50 group will receive ephedrine after the consent and detailed history the two groups will receive preload of 500ml enter acetate then dormicum for sedation then spinal anesthesia will be performed initial blood pressure and heart rate will be measured then every five minutes

Enrollment: 100 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients undergoing Caesarian Section under spinal anesthesia,
• Patients aged 18-45 years,
• At term (≥37-week gestation),
• American Society of Anaesthesiologists (ASA) physical status 1 or 2 Exclusion Criteria:
• Pre-eclampsia,
• Chronic hypertension, cardiovascular troubles,
• Any contraindication to regional anesthesia such as local infection or bleeding disorders,
• Any hypersensitivity to ketamine.
• Declined informed consent.
• American Society of Anaesthesiologists (ASA) physical status lll or lV

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Ketamine group

Active Comparator group

Description:

0.5mg/kg ketamine

Treatment:

Drug: Ketalar

Ephedrine group

Active Comparator group

Description:

15 mg ephedrine

Treatment:

Drug: Ephedrine