Ketone Esters and Metabolism During Recovery from Endurance Exercise

University of Bath

Status: Active, not recruiting

Conditions: Metabolism; Exercise

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Ketone ester

Study type: Interventional

Funder types: Other

Identifiers

NCT06846840

5202-6834

Details and patient eligibility

About

Infusion of beta-hydroxybutyrate can suppress endogenous glucose production, which may result in increased net liver glycogen storage. If ketone esters exert similar effects, then the increase in liver glycogen storage may have implication for recovery from exercise and subsequent exercise performance.

The aim of this study is to assess the effects of ketone esters ingested during recovery from exercise, on metabolism and subsequent exercise capacity.

Enrollment: 18 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• VO2max ≥ 45mL.kg-1.min-1
• Weekly aerobic training > 3hours.
• 2years running experience.
• BMI < 30kg/m2

Exclusion criteria

• <18yrs or >60yrs of age
• Habitual smoker within last 5 years.
• History of uncontrollable metabolic or respiratory disease.
• Currently taking medication, following a low carbohydrate or ketogenic diet, or consuming nutritional ketone supplements.
• History of Irritable Bowel Syndrome

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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18 participants in 2 patient groups, including a placebo group

PLACEBO

Placebo Comparator group

Description:

Energy matched placebo containing medium-chain triglycerides and bitter taste

Treatment:

Dietary Supplement: Placebo

KETONE

Experimental group

Description:

Beta-hydroxybutyrate monoester

Treatment:

Dietary Supplement: Ketone ester