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Ketone Levels Achieved After Medium Chain Triglyceride (MCT) Oil

U

University of Alberta

Status

Completed

Conditions

Pharmacokinetics

Treatments

Dietary Supplement: Medium Chain Triglyceride oil

Study type

Interventional

Funder types

Other

Identifiers

NCT04389983
00087958

Details and patient eligibility

About

Assessing Ketone levels achieved after varying doses of Medium Chain Triglyceride (MCT) oil

Full description

Assessing Ketone levels achieved after varying doses of Medium Chain Triglyceride (MCT) oil in three study populations: <65 year healthy, 65 and older healthy, and Alzheimer's disease.

Each subject attends for 4 study days, receiving incrementally larger MCT doses at each visit for 0g, to 14g, to 28g to 42g.

Enrollment

25 patients

Sex

All

Ages

21+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • adult, healthy or with AD

Exclusion criteria

  • unable to attend all study days
  • coconut allergy
  • Diabetes

Trial design

Primary purpose

Health Services Research

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

25 participants in 3 patient groups

Healthy, under 65 years
Active Comparator group
Description:
Four study days. Day 1 administered 0g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 2 administered 14g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 3 administered 28g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 4 administered 42g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter (All MCT doses administered as a single dose at time 0)
Treatment:
Dietary Supplement: Medium Chain Triglyceride oil
Healthy, over 65 years
Active Comparator group
Description:
Four study days. Day 1 administered 0g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 2 administered 14g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 3 administered 28g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 4 administered 42g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter. (All MCT doses administered as a single dose at time 0)
Treatment:
Dietary Supplement: Medium Chain Triglyceride oil
Alzheimer's Disease subjects
Active Comparator group
Description:
Four study days. Day 1 administered 0g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 2 administered 14g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 3 administered 28g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 4 administered 42g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter. (All MCT doses administered as a single dose at time 0)
Treatment:
Dietary Supplement: Medium Chain Triglyceride oil

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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