Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

McMaster University

Status: Enrolling

Conditions: High Altitude Hypoxia; Exercise

Treatments: Dietary Supplement: Ketone Monoester (KME); Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT07063732

KETEX_WM

Details and patient eligibility

About

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Enrollment: 14 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California

Exclusion criteria

• BMI > 30
• No prescribed medications (oral contraceptives excluded)
• History of smoking
• Currently following a ketogenic diet or consuming exogenous ketogenic supplements
• History of heart, lung, blood vessel, or kidney disease
• Currently pregnant

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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14 participants in 2 patient groups

High Altitude (3800m; Barcroft Research Station)

Experimental group

Description:

High altitude setting

Treatment:

Dietary Supplement: Placebo

Dietary Supplement: Ketone Monoester (KME)

Low Altitude (334m; University of Guelph)

Experimental group

Description:

Low altitude setting

Treatment:

Dietary Supplement: Placebo

Dietary Supplement: Ketone Monoester (KME)