Ketone Production With Acute Caffeine Intake

U

Université de Sherbrooke

Status

Completed

Conditions

Healthy Adults

Treatments

Dietary Supplement: Caffeine high dose
Dietary Supplement: Caffeine low dose
Dietary Supplement: Control

Study type

Interventional

Funder types

Other

Identifiers

NCT02694601
2014-441

Details and patient eligibility

About

Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).

Full description

The aim of the study is to evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10). Two different doses of caffeine (2.5 mg/kg of BW and 5 mg/kg of BW) are compared. All the participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations.

Enrollment

10 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy adults
  • 18 years old and over

Exclusion criteria

  • Drinking more than 300 mg of caffeine per day
  • Diabetes or prediabetes
  • Abnormal liver and kidney function
  • Uncontrolled dyslipidemia, blood pressure
  • Use of drugs known to influence the metabolism of lipids and carbohydrates (steroid, beta-blockers, diuretics, insulin sensitizer, etc.)
  • Severe inflammation or infection
  • Pregnancy
  • Smoking

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

Ketonemia following caffeine intake
Experimental group
Description:
Participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations. Intervention 1: Control; no caffeine intake Intervention 2: Caffeine low dose (2.5 mg/kg of BW) Intervention 3: Caffeine high dose (5.0 mg/kg of MW)
Treatment:
Dietary Supplement: Control
Dietary Supplement: Caffeine low dose
Dietary Supplement: Caffeine high dose

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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