Ketone Production With Acute Caffeine Intake

Université de Sherbrooke

Status: Completed

Conditions: Healthy Adults

Treatments: Dietary Supplement: Caffeine high dose; Dietary Supplement: Caffeine low dose; Dietary Supplement: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT02694601

2014-441

Details and patient eligibility

About

Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).

Full description

The aim of the study is to evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10). Two different doses of caffeine (2.5 mg/kg of BW and 5 mg/kg of BW) are compared. All the participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adults
• 18 years old and over

Exclusion criteria

• Drinking more than 300 mg of caffeine per day
• Diabetes or prediabetes
• Abnormal liver and kidney function
• Uncontrolled dyslipidemia, blood pressure
• Use of drugs known to influence the metabolism of lipids and carbohydrates (steroid, beta-blockers, diuretics, insulin sensitizer, etc.)
• Severe inflammation or infection
• Pregnancy
• Smoking

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Ketonemia following caffeine intake

Experimental group

Description:

Participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations. Intervention 1: Control; no caffeine intake Intervention 2: Caffeine low dose (2.5 mg/kg of BW) Intervention 3: Caffeine high dose (5.0 mg/kg of MW)

Treatment:

Dietary Supplement: Control

Dietary Supplement: Caffeine low dose

Dietary Supplement: Caffeine high dose