Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study

University of Aarhus

Status: Completed

Conditions: Ketone Body Metabolism; Brain Metabolism

Treatments: Drug: placebo; Drug: ketone

Study type: Interventional

Funder types: Other

Identifiers

NCT02357550

RM-1-10-72-106-14

Details and patient eligibility

About

This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion.

Hypotheses

1. Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia.
2. Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow.
3. Altered oxygen consumption during hyperketonemia in healthy subjects.

Enrollment: 9 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• BMI 20-30 kg/m2

Exclusion criteria

• smoking
• alcohol abuse
• severe comorbidity
• blood donation 6 month prior
• claustrophobia

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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9 participants in 2 patient groups, including a placebo group

Control

Placebo Comparator group

Description:

Saline infusion. FDG-PET Scan. O2-PET scan. H2O-PET scan Muscle biopsy

Treatment:

Drug: placebo

Hyperketonaemia

Experimental group

Description:

Ketone infusion. FDG-PET Scan. O2-PET scan. H2O-PET scan Muscle biopsy

Treatment:

Drug: ketone