Key Longitudinal Associations With Risk and Glioblastoma Outcomes (Key LARGO)

Duke University

Status: Enrolling

Conditions: Glioblastoma

Study type: Observational

Funder types: Other

Identifiers

NCT06625684

Pro00114859

Details and patient eligibility

About

The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer.

The main questions it aims to answer are:

• How do genetic and immune system factors impact survival and quality of life in GBM patients?
• What occupational and medical history factors are linked to the risk of getting GBM?

Participants will:

• Fill out an online survey about their medical history and lifestyle.

Participants will have the chance to give a blood sample (from the outer arm) for genetic and immune system testing. Blood samples will be given using a home collection kit provided by the study team.

Full description

This observational study aims to investigate the various factors influencing outcomes and risks in adults diagnosed with glioblastoma (GBM). Glioblastoma is a highly aggressive and malignant brain tumor, and understanding the factors that affect patient outcomes is crucial for improving management strategies and patient care.

The study employs a case-only design where participants will be followed over time to observe how different factors affect their health outcomes. Participants will be selected based on their diagnosis of glioblastoma and will be included in the study regardless of current treatment status or disease stage.

Findings from this study are expected to provide valuable insights into the factors affecting glioblastoma outcomes and may contribute to the development of personalized treatment strategies and risk assessment tools for better management of the disease.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• At least 18 years old
• Pathologically-confirmed diagnosis of glioblastoma multiforme (GBM) or grade 4 brain tumor
• Participant is accessible for follow-up (has a working email address)
• Participant is willing and able to comply with the study requirements

Exclusion criteria

• Those who cannot read either English or Spanish
• Those who cannot view an online survey

Trial design

200 participants in 1 patient group

Adults with Glioblastoma

Description:

This group consists of adults diagnosed with glioblastoma, a type of aggressive brain tumor. Participants are observed to identify factors influencing their outcomes, including genetic, immunologic, and personal medical history factors. The study aims to explore how these factors impact survival rates and quality of life in this patient population. There are no specific interventions. Instead, the focus is on analyzing survey data and biological samples to understand risk factors and disease progression.