Kidney Cancer DNA Registry

Memorial Sloan Kettering Cancer Center (MSK)

Status: Enrolling

Conditions: Renal Cancer

Treatments: Behavioral: Family History Questionnaire (when applicable); Behavioral: the Kidney Cancer Questionnaire; Behavioral: Epidemiologic Questionnaire; Other: Blood draw; Other: salvia for germline DNA

Study type: Observational

Funder types: Other

Identifiers

NCT02087852

13-218

Details and patient eligibility

About

This registry will help us develop better methods of:

• Preventing these cancers
• Diagnosing these cancers
• Treating these cancers

Enrollment: 750 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Kidney Cancer Case Cohort:

• Must be ≥ 18 years of age AND
• Must be an English-speaker AND
• Must have a diagnosis or suspicion of kidney cancer

Family Member Cohort:

• Must be ≥ 18 years of age AND
• Must be an English-speaker AND
• Must be a blood relative of the proband. Family members of probands including mother, father, sisters, brothers, half-sisters, half-brothers, daughters, sons, grandmothers, grandfathers, as well as aunts and uncles are eligible. These individuals need not have kidney cancer, as they will be used for segregation analysis of suspected variants found in the proband; requesting DNA from relatives is required.

Control Cohort:

• Must be ≥ 18 years of age AND
• Must be an English-speaker AND
• Must not have a personal history of cancer, with the exception of nonmelanoma skin cancer, AND
• Must not be a blood relative of any cases or controls enrolled in this study

Exclusion criteria

• Patients who, in the opinion of the primary MSKCC clinician or the investigator, have a condition that precludes their ability to provide an informed consent

Trial design

750 participants in 4 patient groups

kidney cancer patients receiving care at MSKCC

Description:

Participation will consist of completing the Kidney Cancer Questionnaire Family History Questionnaire and complete the Epidemiologic Questionnaire (when applicable,), and providing a blood sample and saliva sample for germline DNA. In cases where tissue samples from surgically derived tumor specimens are obtained these will used to determine genetic alterations related to cancer predisposition or pathogenicity.

Treatment:

Other: salvia for germline DNA

Other: Blood draw

Behavioral: Epidemiologic Questionnaire

Behavioral: the Kidney Cancer Questionnaire

Behavioral: Family History Questionnaire (when applicable)

relatives of patients with kidney cancer

Description:

Participation will consist of completing the Kidney Cancer Questionnaire Family History Questionnaire (when applicable,), and providing a saliva sample for germline DNA. In cases where tissue samples from surgically derived tumor specimens are obtained these will used to determine genetic alterations related to cancer predisposition or pathogenicity.

Treatment:

Other: salvia for germline DNA

Behavioral: the Kidney Cancer Questionnaire

Behavioral: Family History Questionnaire (when applicable)

healthy controls who are unrelated & do not have hx of cancer

Description:

Participation will consist of completing the Kidney Cancer Questionnaire Family History Questionnaire (when applicable,), and providing a saliva sample for germline DNA. In cases where tissue samples from surgically derived tumor specimens are obtained these will used to determine genetic alterations related to cancer predisposition or pathogenicity.

Treatment:

Other: salvia for germline DNA

Behavioral: the Kidney Cancer Questionnaire

Behavioral: Family History Questionnaire (when applicable)

high risk

Description:

Participation will consist of completing the Epidemiologic Questionnaire, Family History Questionnaire (if + FH), provide saliva and blood sample , referral for screening evaluation

Treatment:

Other: salvia for germline DNA

Other: Blood draw

Behavioral: Epidemiologic Questionnaire

Behavioral: Family History Questionnaire (when applicable)