Kidney Function After Pneumoperitoneum and Analgesia

UPECLIN HC FM Botucatu Unesp

Status: Completed

Conditions: Laparoscopic Cholecystectomy

Study type: Observational

Funder types: Other

Identifiers

NCT00914875

upeclin/HC/FMB-Unesp-25

Details and patient eligibility

About

double blind study of kidney function of two groups of adult patients submitted to laparoscopic cholecystectomy and analgesia from tramadol associated to dipyrone or ketorolac

Full description

Background: The laparoscopic cholecystectomy (LC) reduces surgical trauma and hospital stay but requires effective and safe postoperative analgesia. This prospective and double blind study aimed to study the effects of tramadol analgesia associated to dipyrone or ketorolac in the kidney function of patients submitted to LC, using creatinine (Cr), cystatin C, and enzymuria evaluations.

Methods: In the pre- and postoperative (PO) periods, estimated glomerular filtration rates (GFR), obtained from two formulas dependants of blood Cr and one from blood cystatin C values, and tubular enzymuria - alkaline phosphatase (AP), γ-glutamyltransferase (γ-GT) - were determined in patients who underwent LC and analgesia with tramadol and dipyrone (G1, n=63) or tramadol and ketorolac (G2, n=63). In the recovery room (RR), pain and need of rescue analgesia with morphine were evaluated.

Enrollment: 126 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• From 18 to 60 years
• Normal kidney function
• Free consented participation

Exclusion criteria

• Renal and hepatic dysfunction
• Prior (one month) use of anti-inflammatory agents

Trial design

126 participants in 2 patient groups

group tramadol plus ketorolac

group tramadol plus dypirone