Kidney Function in Obese Women

Wissal Abassi

Status: Completed

Conditions: Kidney Function Tests

Treatments: Behavioral: walking intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT06905236

Training and kidney

Details and patient eligibility

About

The goal of this clinical trial is to investigate the impact of a 10-week moderate intensity interval walking training (MIIWT) program on kidney function markers in obese postmenopausal women. The main question it aims to answer is:

Does MIIWT improve kidney function markers in this population? Researchers will compare MIIWT (designed to training group) to non-training intervention (designed to control group) to see if the training program works to improve kidney function markers.

Participants in training group will: perform a 10-week MIIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.

Full description

The convergence of the obesity pandemic and the postmenopausal status is likely associated with renal function decline. Regular aerobic training have been shown to prevent adverse health outcomes in obese. The main purpose of this study was to evaluate changes in kidney function markers and white blood cell (WBC) subpopulations in obese postmenopausal women participating in moderate intensity interval walking training (MIIWT). A total of 36 obese postmenopausal women were randomized to MIIWT (CON, n=18) or control group (CON, n=18), four times a week for 10-week. The MIIWT consisted on 5 repetitions of walking for 6-min at 60-80% of the 6-min-walk-test-distance with 6-min of active recovery between repetitions. Before and after the MIIWT, body composition, kidney function markers (serum creatinine [sCr], blood urea nitrogen [BUN], serum uric acid [sUA] and Glomerular Filtration Rate [GFR] and white blood cells (WBC) count and its specific subpopulations (neutrophils [NEU], lymphocytes [LYM], monocytes [MON], eosinophils [EOSI] and basophils [BASO]) were assessed.

Enrollment: 36 patients

Sex: Female

Ages: 50 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• be aged between 50 and 60 years.
• be postmenopausal (absence of menses > 12 months).
• present a BMI greater than or equal to 30 kg/m2.
• be free of any special diets in the three months prior to the start of the intervention.
• have a sedentary lifestyle (exercise less than 2 h/week).

Exclusion criteria

• Suffering from any cardiovascular/renal/pulmonary/metabolic disease.
• Being under menopausal hormone therapy.
• Presenting any orthopedic limitations interfering the ability to perform the study intervention.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

Training group

Experimental group

Description:

The training group underwent a moderate intensity intermittent walking training at 60% to 80% of the 6- min-walking-test distance, four times a week of 60 min/session for a period of 10 weeks.

Treatment:

Behavioral: walking intervention

Control group

No Intervention group

Description:

No training intervention was intended for the control group.