Kidney Function Indexed Extracellular Volume Before and After Obesity Surgery

Centre Hospitalier Universitaire de Nice

Status

Unknown

Conditions

Obesity

Treatments

Other: DFG mesure

Study type

Interventional

Funder types

Other

Identifiers

NCT02830646

14-AOI-09

Details and patient eligibility

About

Obesity promotes chronic kidney disease and is accelerating its shift to the stage of renal replacement. Bariatric surgery is a treatment for severe or morbid obesity whose renal benefit is currently unknown. The glomerular filtration rate (GFR) is the best parameter to define the kidney function. It can be estimated using formulas by assaying endogenous markers (creatinine, cystatin C) or measured with an exogenous tracer glomerular filtration (51 Cr-EDTA).

Bariatric surgery alters the production of endogenous markers and the extracellular volume (VEC) with 2 important consequences on the assessment of GFR: the formula to estimate GFR is not possible to compare renal function before and after surgery because of the variation in production of endogenous glomerular filtration markers in the same subject; decreasing VEC predicted decreased GFR after surgery, since these parameters are in part proportional to each other.

Our working hypothesis is that bariatric surgery protects the kidneys of patients with chronic kidney disease. To demonstrate this, investigators propose to compare the ratio DFG / VEC before and after gastric bypass.

Goals The main objective is to measure the effect of gastric bypass on the report DFG / VEC. Secondary objectives are to assess the effect of gastric bypass on the albumin / urine creatinine and evaluate the performance of the main GFR estimating formulas in people with severe or morbid obesity.

Enrollment

14 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Topic GFR estimated by having the simplified formula of MDRD <60 ml / min / 1.73 m²
Topic with BMI ≥ 40 kg / m², or ≥ 35 kg / m²
Subject having at least one comorbidity could be improved after surgery after failure of medical treatment: hypertension , OSAHS and other severe respiratory disorders, severe metabolic disorders, particularly type 2 diabetes , debilitating musculoskeletal diseases, steatohepatitis nonalcoholic .
Topic who signed the informed consent
Topic affiliated to the social security
Male or female Topics
Elderly 18 to 70 inclusive

Exclusion criteria

Non- Caucasian person because the necessary correction factors and not always available for the formula to estimate GFR ( Cockcroft , Salazar and Corcoran ) .
No major under guardianship
Nobody hospitalized without his consent and not protected by law
Private person of liberty
Pregnant Woman, knowing that a pregnancy test will be performed for women of childbearing age . Results will be communicated to the patient by a doctor of his choice.
Rapidly progressive glomerulonephritis
Nephrotic proteinuria ranking