Kidney Graft Tolerance KTOL

Nantes University Hospital (NUH)

Status: Enrolling

Conditions: Kidney Transplant Tolerance

Study type: Observational

Funder types: Other

Identifiers

NCT06271343

RC23_0394

Details and patient eligibility

About

Prospective experimental study using PBMC from a limited number of adult patients (15) treated at Nantes University Hospital for a kidney transplant from a related living donor.

The study will be carried out on PBMC from both donors and recipients, collected during visits scheduled as part of the clinical management of the donor/recipient pair.

The study will test the hypothesis that DP8α Tregs expressing CD73, whose frequency in blood increases stably after non-rejected kidney transplants, but not when patients have undergone or will subsequently undergo rejection, are enriched in donor-specific cells, which would be a strong argument in favor of a direct role for these Tregs in preventing transplant rejection, through their ability to inhibit immune responses directed against donor alloantigens.

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult donor-recipient pair.
• First or second kidney transplant from a related ABO-compatible living donor.
• BMI < 35 for recipients.
• Adult patients.
• Patients weighing over 50 kgs.

Exclusion criteria

• Donor/recipient ABO incompatibility
• BMI > 35 for recipients

Trial design

15 participants in 2 patient groups

Donor patients

Recipient patients