Kinetics and Ecology of Human Papillomavirus Genital Infections in Young Women (PAPCLEAR)

University Hospital Center (CHU)

Status

Terminated

Conditions

HPV Genital Infection (Primary Condition Studied)

Chlamydiae Infection

Bacterial Vaginosis

Treatments

Other: vaginal sampling

Study type

Interventional

Funder types

Other

Identifiers

NCT02946346

2016-A00712-49 (Registry Identifier)

RECHMPL16_0149

Details and patient eligibility

About

Most genital infections by human papillomaviruses (HPV) are asymptomatic or benign and clear within a few months or years. There infections are much less studies than chronic infections, even though they represent the main reservoir for the virus. The goal of this project is to decipher the kinetics of the virus and of the host immune response in acute HPV genital infections in your women. This will be performed by following women longitudinally and regularly in order to measure variations in virus load, immune cell count, cytokine concentration and antibody titers. The investigators will also investigate the interaction between these kinetics and host genetics and host vaginal microbiota

Enrollment

190 patients

Sex

Female

Ages

18 to 25 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Sexually active with at least one new partner over the last 12 months
Subjects must be able and willing to give written informed consent
Living in the 'agglomération de Montpellier'

Exclusion criteria

History of cervical pathology
Pregnant or intending to become pregnant soon (in the coming year)
Infected by HIV
Undergoing (or planning to undergo) heavy treatment (biotherapy, chemotherapy, immunosuppression)
Participation in a clinical trial involving administration of drugswithin the last 4 weeks before the screening date