Kinetics of Biomarkers in Acute Pyelonephritis

University Hospitals (UH)

Status: Completed

Conditions: Pyelonephritis

Study type: Observational

Funder types: Other

Identifiers

NCT00805181

PRD-08-I-4

CER08-170

Details and patient eligibility

About

The objective of this study is to explore the kinetics of biomarkers in 30 adult female patients with uncomplicated acute pyelonephritis.

Full description

We will measure c-reactive protein, procalcitonin, pyuria and a new blood biomarker (Signature TM) everyday till normalization of these markers in 30 adult female patients with uncomplicated acute pyelonephritis.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• > 18 years
• Flank/loin pain or tenderness, or both and fever > 38°C during the last 48 hours and pyuria

Exclusion criteria

• Pregnancy
• Presence of indwelling catheters
• Known polycystic kidney disease or any malformation of the urinary tract, or single kidney; renal transplant recipients; acute or chronic renal failure requiring dialysis
• Recent discharge from hospital (during the last 10 days); ongoing antibiotic treatment
• Known severe immunosuppression: Receiver of solid-organ or hematopoietic stem cells transplants; neutropenia ( < 1 G neutrophils / L); chronic (more than 14 days) use of systemic glucocorticoids (>10 mg/d of prednisone); active use of immunosuppressive therapy for the treatment of auto-immune or inflammatory disease; HIV infection with < 350 CD4+ cells / ml or unknown CD4+ status
• Pyelonephritis initially identified as complicated: obstruction of urinary tract, urinary stone; history of renal infection in the last 15 days
• Patient with severe sepsis or septic shock

Trial design

30 participants in 1 patient group

Acute uncomplicated pyelonephritis