Kinetics of Inflammation Markers in Maternal Plasma: Study of the Correlation With the Diagnosis of Chorioamnionitis in Women Hospitalized for Spontaneous Rupture of the Fetal Membranes

University Hospital Center (CHU) Dijon Bourgogne

Status: Terminated

Conditions: Patients With Spontaneous Rupture of the Fetal Membranes

Treatments: Other: Blood samples

Study type: Interventional

Funder types: Other

Identifiers

NCT01903759

Sagot PHRC IR 2006

Details and patient eligibility

About

The principal aim of this study is to help obstetricians to diagnose chorioamniotic infection early, in cases of premature rupture of the fetal membranes before 34 WA, by proposing earlier and more specific markers of infection than FBC and CRP. The aim is to reduce vital and functional risk of acute chorioamnionitis for the mother, the fetus or the newborn,.

If the kinetics profile of one or several markers correlates strongly with the diagnosis of chorioamnionitis, it could be used in clinical practice, possibly in the context of another clinical study.

The results of the study presented here are destined to be published in obstetrics journals.

Enrollment: 97 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Term between 24 and 34 WA
• Spontaneous rupture of the fetal membranes
• Singleton pregnancy
• Age > 18 years

Exclusion criteria

• Delivery within the hour following admission
• Hospitalisation before 24 WA or after 34 WA
• Hemorrhagic placenta previa or retroplacental hematoma, known auto-immune or inflammatory disease
• Infection with human immunodeficiency virus (HIV)
• Refusal to provide consent.
• Patients provided for in articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the Public Health Code (e.g.: minors, adults under guardianship, etc...)

Trial design

97 participants in 1 patient group

Patients with spontaneous rupture of the fetal membranes

Other group

Treatment:

Other: Blood samples