Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation (PERIGLUC1)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Candida Infection; Peritonitis Infectious

Treatments: Other: To evaluate the initial levels and kinetics of serum β-D-glucan

Study type: Interventional

Funder types: Other

Identifiers

NCT03140748

PI2016_843_0036

Details and patient eligibility

About

Intraabdominal fungal infections with Candida are constantly increasing. Their diagnosis and treatment is difficult. Morbidity and mortality are high. Β-D-Glucan has been proposed as a marker of systemic fungal infection in candidemia. Moreover, its kinetics is associated with therapeutic success. On the other hand, there are no data on intraabdominal infections that are much more frequent. The objective of the study is to evaluate the initial levels of β-D-glucan and its daily kinetics during the treatment of fungal peritonitis in resuscitation compared to a control group with a yeast-free peritonitis.

Enrollment: 70 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major Patient (age ≥ 18 years)
• Community or associated peritonitis, operated and hospitalized in resuscitation
• Affiliation to a social security scheme

Exclusion criteria

• Allergy known to echinocandins
• Dying Patient
• Limitation of care
• Predictable duration of follow-up ≤ 10 days
• Transfusion within 3 months
• Patient minor, patient under guardianship or curatorship

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

Patients with fungal peritonitis

Other group

Treatment:

Other: To evaluate the initial levels and kinetics of serum β-D-glucan

Patients with peritonitis without yeast

Other group

Treatment:

Other: To evaluate the initial levels and kinetics of serum β-D-glucan