Kinetics of the Finasteride Prostate Induced Apoptosis

Civil Hospices of Lyon

Status and phase: Unknown; Phase 4

Conditions: Benign Prostatic Hyperplasia

Treatments: Drug: finasteride

Study type: Interventional

Funder types: Other

Identifiers

NCT00130767

2003.316

Details and patient eligibility

About

The aim of this study is to evaluate the mechanisms involved in the apoptosis induced by a treatment of finasteride on benign prostate hyperplasia (BPH). Five sets of patients who need a surgical procedure because of low tract urinary symptoms are randomly attributed to one of five sets of treatment: 0, 7, 14, 21 or 28 days of finasteride treatment before the day of the procedure. Prostate histological fragments are conditioned for molecular and histologic studies.

Sex: Male

Ages: 40 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients with low tract urinary symptoms needing a surgical procedure
• No previous treatment with finasteride
• No androgen deficiency; no prostate cancer suspected.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)