Kisspeptin/GPR54 Pathway and Early Puberty

Shenzhen Center for Disease Control and Prevention

Status: Completed

Conditions: Puberty, Precocious

Treatments: Other: this study was an observational study and no interventions were given to the participants

Study type: Observational

Funder types: Other

Identifiers

NCT04012632

szCDC_1

Details and patient eligibility

About

There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.

Enrollment: 628 patients

Sex: Female

Ages: 7 to 10 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion criteria

• The participants who were not the first visit to the hospital and had been treated before.
• The participants who were with endocrine disorders.

Trial design

628 participants in 2 patient groups

cases

Description:

Early puberty cases of Han Chinese

controls

Description:

Controls were matched to cases at 1:1 by age (± 3 months)

Treatment:

Other: this study was an observational study and no interventions were given to the participants