(KIWI) Speeding up a Slow Protein for Muscle Mass With Hay Kiwifruit

University of Arkansas

Status: Completed

Conditions: Metabolism; Protein

Treatments: Dietary Supplement: Green Hayward Kiwifruit first, then Gold Kiwifruit; Dietary Supplement: Gold Kiwifruit First, then Green Hayward Kiwifruit

Study type: Interventional

Funder types: Other

Identifiers

NCT04356573

206814

Details and patient eligibility

About

The specific hypothesis is that the consumption of 2 Hayward green kiwifruit (containing actinidin protease) prior to 100g of ground beef will increase the rate of protein digestion from the beef in the elderly, leading to an increased uptake of the essential amino acids. Furthermore, this increased essential amino acid availability will produce a greater postprandial net anabolic protein response, as well as increased fractional synthetic rates of muscle proteins.

Full description

The specific hypothesis is that the consumption of 2 Hayward green kiwifruit (containing actinidin protease) prior to 100g of ground beef will increase the rate of protein digestion from the beef in the elderly, leading to an increased uptake of the essential amino acids. Furthermore, this increased essential amino acid availability will produce a greater postprandial net anabolic protein response, as well as increased fractional synthetic rates of muscle proteins.

To test this hypothesis, the investigators will use a double-blinded crossover design involving two intervention arms; in both arms 100g of ground beef (cooked weight) will be consumed following either 2 Hayward green kiwifruit (containing actinidin protease) or 2 Hort16A Gold kiwifruit (devoid of actinidin protease) by elderly subjects.

Enrollment: 13 patients

Sex: All

Ages: 60 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• men and women ages 60-85 inclusive.

Exclusion criteria

• Inability to chew meats or difficulty swallowing solid foods
• History of diabetes
• History of malignancy in the 6 months prior to enrolment
• History of gastrointestinal reduction or bypass surgery (Lapband, etc)
• History of a chronic inflammatory condition or disease (Lupus, HIV'AIDS, etc)
• History of chronic kidney disease or currently requiring dialysis.
• Allergy to beef or kiwifruit
• Subjects who do not or will not eat animal proteins
• Subjects who cannot refrain from consuming protein or amino acid supplements during their participation in this study
• Subjects who report regular resistance exercise (more than once per week)
• Hemoglobin less than 9.5mg/dL at the screening visit
• Platelets less than <150,000 at the screening visit
• Subjects who are not willing or able to suspend aspirin for several days prior to their muscle biopsies.
• Subjects who have been prescribed a blood-thinning medication (Coumadin, lovenox, heparin, Plavix, etc).
• Concomitant use of corticosteroids (ingestion, injection or transdermal)
• Any other disease or condition that would place the subject at increased risk of harm if they were to participate, at the discretion of the study physician

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

---

13 participants in 2 patient groups, including a placebo group

Gold Kiwifruit First, then Green Hayward Kiwifruit

Placebo Comparator group

Description:

Subjects first ate 2 gold kiwifruit with midday meal for 2 weeks before crossing over to the green Hayward kiwifruit intervention

Treatment:

Dietary Supplement: Green Hayward Kiwifruit first, then Gold Kiwifruit

Dietary Supplement: Gold Kiwifruit First, then Green Hayward Kiwifruit

Green Hayward Kiwifruit first, then Gold Kiwifruit

Active Comparator group

Description:

Subjects first ate 2 green Hayward kiwifruit with midday meal for 2 weeks before crossing over to the gold kiwifruit intervention

Treatment:

Dietary Supplement: Green Hayward Kiwifruit first, then Gold Kiwifruit

Dietary Supplement: Gold Kiwifruit First, then Green Hayward Kiwifruit