Knee Injections for Obese Patients With Knee Arthritis

Mayo Clinic

Status and phase: Enrolling; Phase 4

Conditions: Osteoarthritis of Knee

Treatments: Drug: Triamcinolone Acetonide Low Dose; Drug: Triamcinolone Acetonide Standard Dose

Study type: Interventional

Funder types: Other

Identifiers

NCT06782529

24-005200

Details and patient eligibility

About

The purpose of this study is to assess obese patients with knee arthritis and determine the non-inferiority of a low dose steroid treatment vs. standard dose steroid treatment for two knee outcome measures: pain and function.

Enrollment: 40 estimated patients

Sex: All

Ages: 55 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with BMI ≥30 kg/m2 and radiograph-proven knee osteoarthritis who are interested in receiving a steroid injection for knee arthritis.

Exclusion criteria

• BMI < 30 kg/m2
• Uncontrolled diabetics with a hemoglobin A1c > 8%
• No other treatment within the time frame of the study.
• Patients that are undergoing physical therapy at the time of the study.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Standard Dose Group

Active Comparator group

Description:

Patients with knee osteoarthritis who are interested in knee intra-articular corticosteroid injections and meet the inclusion criteria.

Treatment:

Drug: Triamcinolone Acetonide Standard Dose

Lower Dose Group

Experimental group

Description:

Patients with knee osteoarthritis who are interested in knee intra-articular corticosteroid injections and meet the inclusion criteria.

Treatment:

Drug: Triamcinolone Acetonide Low Dose