Knee Osteoarthritis Risk in Retired Professional Footballers

University of Nottingham

Status

Unknown

Conditions

Osteoarthritis of the Knee

Study type

Observational

Funder types

Other

Identifiers

NCT02098044

13130

Details and patient eligibility

About

The OA and Football Study is an epidemiological study designed to establish the prevalence of knee osteoarthritis in retired professional footballers. The study will also identify the key risk factors associated with knee osteoarthritis. The study is comprised of three phases: Phase I involves the dissemination of a questionnaire (demographic details, players history, injury and surgery and other known risk factors of OA), Phase II is a radiographic study that involves x-rays in a sample of footballers both with and without knee pain and Phase III is a case control study which will compared retired professional footballers with age-matched controls recruited from the general population in the East Midlands region.

Full description

Number of Participants:

Phase I: 1000 Phase II: 855 Phase III: 500

Primary outcome: The questionnaire will contain player specific information and will include validated outcome measures such as the health status questionnaire as well as self-reported pain, recall of injury and surgery history. The results of the questionnaire will be exported firstly to Excel and subsequently, into MS Access as part of a managed database.

Enrollment

1,300 patients

Sex

Male

Ages

40 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Phase I

Inclusion Criteria:

• All current or retired professional male footballers (Registered with the Professional Footballer Association (age range 40 -80)

Phase II

Inclusion Criteria:

Professional footballers both with and without a history of knee pain knee OA or knee surgical history
No contraindications of the affected joint such as gout or rheumatoid arthritis
Willingness to participate in a clinical assessment of the knee and provision of blood samples.

Phase III

Inclusion Criteria for controls:

Over the age of 40 (age range 40 - 80)
Both with and without a history of knee pain over at least the last 1 year
No history of significant trauma, injury or surgery to the lower limb
American College of Rheumatology (ACR) classification of OA based on physical examination and clinical presentation: Pain in the knee and three of the following; over the age of 50, less than 30 minutes of morning stiffness, crepitus on active motion, bony tenderness, bony enlargement and no palpable warmth of synovium.

Phase I

Exclusion Criteria:

Not a registered professional footballer (current or past)
Inaccurate information (discrepancy with questionnaire information compared to other football records. This will be verified by the co-investigator, Dr Fernandes and Mr Sanjay Parekh)
Incomplete questionnaire or duplicate questionnaire.

Phase II

Exclusion Criteria: