Korean Red Ginseng and Metabolic Syndrome

The Korean Society of Ginseng

Status: Completed

Conditions: Metabolic Syndrome

Treatments: Dietary Supplement: Korean red ginseng; Dietary Supplement: starch

Study type: Interventional

Funder types: Other

Identifiers

NCT00976274

3-2009-0015

Details and patient eligibility

About

Five factor consisting of Metabolic syndrome is closely linked by insulin resistance. Until now, several studies have been performed about effects of Korea red ginseng on hypertension, diabetes, and hyperlipidemia, but not metabolic syndrome.

The investigators hypothesize that Korean red ginseng could improve each constituents of metabolic syndrome, arterial stiffness, and inflammatory markers.

The aim of this study is to determine effects of Korean red ginseng on cardiovascular risks in subjects with metabolic syndrome.

Full description

The details of study objective are followed by these:

• comparison of blood pressure before and after Korean red ginseng administration
• comparison of metabolic indicator before and after Korean red ginseng administration
• comparison of oxidative stress and inflammatory markers before and after Korean red ginseng administration
• comparison of arterial stiffness before and after Korean red ginseng administration

Enrollment: 60 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:(three or more of following five factors)

• waist circumference(male: more than 90cm, female: more than 80cm)
• blood pressure(systolic: more than 130mmHg, diastolic: more than 85mmHg)
• fasting plasma glucose: more than 100mg/dL
• fasting triglycerides: more than 150mg/dL
• High-density lipoprotein(HDL)-cholesterol(male: less than 40mg/dL, female: less than 50mg/dL)

Exclusion Criteria: (any one of following factors)

• uncontrolled blood pressure(systolic: more than 160mmHg, diastolic: more than 100mmHg) or subjects taking blood pressure lowering drug
• Type 2 diabetes patients or fasting plasma glucose more than 126mg/dL
• triglyceride more than 400mg/dL, total cholesterol more than 250mg/dL
• subjects taking antilipidemic drug
• past history of coronary heart disease or cerebrovascular disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups, including a placebo group

starch capsule

Placebo Comparator group

Treatment:

Dietary Supplement: starch

Korea red ginseng

Experimental group

Treatment:

Dietary Supplement: Korean red ginseng