Korean Red Ginseng Rg3 Extract on Arterial Stiffness and Blood Pressure (KRAB)

Unity Health Toronto

Status and phase: Completed; Phase 1

Conditions: Arterial Stiffness, Blood Pressure

Treatments: Dietary Supplement: Ginseng; Dietary Supplement: Wheat Bran

Study type: Interventional

Funder types: Other

Identifiers

NCT01951443

KRAB

Details and patient eligibility

About

The purpose of the study is to evaluate the acute effect of a standardized extract of KRG (Rg3-KRG) consisting of 30% total ginsenosides, including 10% Rg3 ginsenoside on arterial stiffness and blood pressure, as measured by the following parameters: aortic augmentation index, peripheral blood pressure, central blood pressure

Enrollment: 24 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Healthy
• Age 18-70 years
• BMI < 30 kg/m2
• Brachial systolic blood pressure < 140 mmHg
• Brachial diastolic blood pressure < 90 mmHg

Main Exclusion Criteria:

• BMI >30kg/m2
• Hypertensive (brachial systolic BP ≥140mmHg and/or diastolic BP ≥90mmHg)
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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24 participants in 2 patient groups, including a placebo group

Ginseng

Experimental group

Description:

Encapsulated 400mg Rg3-KRG extract

Treatment:

Dietary Supplement: Ginseng

Wheat Bran

Placebo Comparator group

Description:

400mg Wheat Bran capsule

Treatment:

Dietary Supplement: Wheat Bran