Krill Oil and Resistance Exercise in Older Adults (KOREA)

University of Glasgow

Status: Completed

Conditions: Sarcopenia

Treatments: Other: Home-based resistance exercise; Dietary Supplement: Krill oil; Dietary Supplement: Vegetable oil

Study type: Interventional

Funder types: Other

Identifiers

NCT05869513

KOREA

Details and patient eligibility

About

The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Hypothesis - krill oil supplementation will enhance the beneficial effects of resistance exercise on muscle strength, function, mass and neuromuscular function in sedentary older adults.

Enrollment: 60 patients

Sex: All

Ages: 60 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Over the age of 60 years
• scoring a low level of physical activity based on international physical activity questionnaire (not meeting the recommend physical activity which is at least 600 MET-min per week).

Exclusion criteria

• Diabetes
• severe cardiovascular disease
• seizure disorders
• uncontrolled hypertension (>150/90mmHg at baseline measurement)
• cancer or cancer that has been in remission <5 years
• ambulatory impairments which would limit ability to perform assessments of muscle function
• dementia
• taking medication known to affect muscle (e.g. steroids)
• have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
• on anticoagulant therapy
• allergies to seafood
• regular consumption of more than 1 portion of oily fish per week
• already taking fish or krill oil or other n3 PUFA supplements
• femoral neck fracture or other severe of hip or knee operations
• stroke
• Parkinson's disease
• COPD
• kidney disease
• hyperlipidaemia
• obesity
• osteoporosis.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups, including a placebo group

Vegetable oil + Resistance exercise

Placebo Comparator group

Description:

4g/day vegetable oil and home based resistance exercise for 16 weeks

Treatment:

Dietary Supplement: Vegetable oil

Other: Home-based resistance exercise

Krill oil + Resistance exercise

Active Comparator group

Description:

4g/day krill oil and home based resistance exercise for 16 weeks

Treatment:

Dietary Supplement: Krill oil

Other: Home-based resistance exercise