KRN125 for Mobilization of Hematopoietic Stem Cells

Kyowa Kirin

Status and phase

Completed

Phase 2

Conditions

Peripheral Blood Stem Cell Transplantation

Treatments

Drug: Pegfilgrastim

Study type

Interventional

Funder types

Industry

Identifiers

NCT03993639

125-101

Details and patient eligibility

About

Data collection to evaluate safety and effect of hematopoietic stem cell mobilization into the peripheral blood after a single subcutaneous (SC) dose of KRN125(Pegfilgrastim)in healthy adults.

Full description

KRN125 is administered as a single SC dose to the Day 1. The stem cell mobilization protocols will be monitored for safety and efficacy during the mobilization period.

Enrollment

35 patients

Sex

All

Ages

20 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Japanese subjects aged 20 to 55 years or younger at the submission of the written informed consent form
Women weighing 40 kg or more and 80 kg or less and men weighing 45 kg or more and 80 kg or less at the time of the preliminary examination

Exclusion criteria

Subjects with a current medical history or who have been judged to be inappropriate for the study (e.g., significant neurological, hepatic, renal, endocrine, cardiovascular, blood, gastrointestinal, respiratory, and metabolic diseases, malignancies, myeloproliferative disorder, or psychiatric disorders)
Individuals with alcohol or drug dependence, or individuals who have not tested negative for all drugs of abuse in the preliminary test
Subjects with a history or current history of drug allergy or symptomatic allergy
.Active infection or history of recurrent infection- However, only patients who are HBsantibody-positive by hepatitis B vaccination and whose HBV-DNA is less than the lower limit of quantitation will be allowed to participate in this study.
Subjects who used drugs within 2 weeks before administration of the investigational drug.
Subjects who have had at least 200 mL of blood drawn within 3 months before administration of the investigational drug.
Pregnant or lactating