L-arginine Effects on Chronic Hypertension in Pregnancy

University of Modena and Reggio Emilia

Status and phase: Completed; Phase 3

Conditions: Hypertension in Pregnancy

Treatments: Drug: L-arginine; Other: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT00974714

De Pace Viviana (Other Grant/Funding Number)

Dante Giulia (Other Grant/Funding Number)

Monari Francesca (Other Grant/Funding Number)

Facchinetti

Neri Isabella (Other Grant/Funding Number)

Details and patient eligibility

About

The purpose of this study is to evaluate the effects of oral L-arginine administration on pregnant women at second trimester of gestation with chronic hypertension, respect with placebo.

Enrollment: 80 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pregnant women between 18-20 weeks of gestation with chronic hypertension

Exclusion criteria

• Other maternal or fetal systemic disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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80 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

Oral L-arginine 2 g twice a day, for 14 weeks

Treatment:

Drug: L-arginine

2

Placebo Comparator group

Description:

oral placebo twice a day for 14 weeks

Treatment:

Other: placebo