L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function

University Hospital, Strasbourg, France

Status and phase: Completed; Phase 4

Conditions: Heart Transplantation

Treatments: Drug: 12 g of L-arginine glutamate during 6 weeks twice a day

Study type: Interventional

Funder types: Other

Identifiers

NCT00213915

3031

Details and patient eligibility

About

• exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction
• cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation
• to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male (> 18 years old) stable heart transplant recipient for at least 6 weeks
• Stable treatment for at least 3 months
• Sedentary people

Exclusion criteria

• Unstable cardiac pathology
• Obesity (IMC > 40)
• Participation in another study in the last month
• Chronic renal failure (creatinine clearance < 20 ml/min)
• Renal transplantation
• Diabetes
• Impossibility to practice exercise test
• Nitrate therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind