L-Arginine, Symmetrical and Asymmetrical Dimethylarginine (SDMA/ADMA) in Acute Kidney Injury (AKI)

Wuerzburg University Hospital

Status: Completed

Conditions: Acute Kidney Injury

Study type: Observational

Funder types: Other

Identifiers

NCT01552525

91/10

Details and patient eligibility

About

The purpose of the study is to determine the association between acute kidney injury and serum levels symmetrical and asymmetrical dimethylarginine (SDMA/ADMA) and their assumptive influence on mortality, renal function and on arterial stiffness.

Full description

Acute kidney injury (AKI) is a frequent complication with severe implications deteriorating overall prognosis. Nitric oxide (NO)-signal transduction plays an important role in mediating renal damage. NO is produced by NO-synthase (NOS) with L-arginine as its substrate. Endogenous L-Arginine derivatives, asymmetric and symmetric dimethylarginines (ADMA/SDMA), inhibit NO-production directly (AMDA) by blocking NOS activity or indirectly (SDMA) by blocking cellular L-Arginine uptake.

It is well known that SDMA and ADMA are markers of renal function (SDMA) and cardiovascular risk (ADMA/SDMA) in patients with chronic kidney disease (CKD). Moreover, ADMA and SDMA possibly even trigger cardiovascular risk in patients with CKD. However, there is only little information about the regulation and the influence of ADMA/SDMA in acute kidney injury.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• acute kidney injury according to the definition of AKIN (Acute Kidney Injury Network)
• no started renal replacement therapy (e.g. dialysis)

Exclusion criteria

• dialysis or continuous venovenous hemofiltration before recruitment
• no recovery from kidney injury according to the definition of AKIN (Acute Kidney Injury Network)
• palliative care
• life expectancy is severely limited (< six months) due to preexisting malignancy or other disease

Trial design

300 participants in 1 patient group

acute kidney injury

Description:

Patients with acute kidney injury according to the definition of AKIN (Acute Kidney Injury Network)