L-Arginine, Vascular Response and Mechanisms

Mass General Brigham

Status and phase: Completed; Phase 2

Conditions: Hypertension; Diabetes

Treatments: Dietary Supplement: L-Arginine; Dietary Supplement: Placebo Supplement

Study type: Interventional

Funder types: Other

Identifiers

NCT01482247

2008A052379

Details and patient eligibility

About

The purpose of the study is to employ the supplement L-arginine to test the hypothesis that activation of blood flow to the brain during cognitive tasks is regulated by nitric oxide in older subjects with diabetes mellitus and/or hypertension (high blood pressure).

Enrollment: 25 patients

Sex: All

Ages: 70+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diabetes and/or hypertension

Exclusion criteria

• alzheimers disease, dementia, stroke, active herpes, recent angina or heart attack

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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25 participants in 2 patient groups, including a placebo group

L-arginine

Active Comparator group

Treatment:

Dietary Supplement: L-Arginine

Placebo Supplement

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo Supplement