L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension

Sherief Abd-Elsalam

Status and phase: Unknown; Phase 4

Conditions: Thalassemia

Treatments: Drug: L-arginine; Drug: Sildenafil

Study type: Interventional

Funder types: Other

Identifiers

NCT03402191

Prof Elshanshoury

Details and patient eligibility

About

This study compares L-arginine Versus Sildenafil as treatment for pulmonary hypertension in Children with Beta Thalassemia

Full description

This study focuses on different lines of treatment for pulmonary hypertension in children with thalassemia as this study discusses the Effect of L-arginine Versus Sildenafil in Children with Beta Thalassemia Associated with Pulmonary Hypertension

Enrollment: 60 estimated patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children with thalassemia and pulmonary hypertension.

Exclusion criteria

• Rheumatic heart diseases.
• Other comorbid disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

L-arginine

Active Comparator group

Description:

l-arginine for pulmonary hypertension in patients with thalassemia.

Treatment:

Drug: L-arginine

Sildenafil

Active Comparator group

Description:

Sildenafil for pulmonary hypertension in patients with thalassemia.

Treatment:

Drug: Sildenafil

Control

No Intervention group

Description:

No pulmonary hypertension