L-carnitine Corrects Ammonia Metabolism in Hepatectomized Patients

K

Kochi University

Status and phase

Unknown
Phase 3
Phase 2

Conditions

Ammonia Metabolism

Treatments

Other: usual intake
Drug: L-carnitine

Study type

Interventional

Funder types

Other

Identifiers

NCT03021876
LAMP study

Details and patient eligibility

About

L-carnitine is synthesized from lysine and methionine. Postmortem concentrations of carnitine in liver, muscle, heart, kidney, and brain averaged only one-fourth to one-third those in corresponding tissues of eight normally nourished non-hepatic patients who died after an acute illness of a 1-3-day duration. In the recent years, it has been reported that sirtuin 3 (SIRT3) is protective against acute kidney injury (AKI) and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury. In the current study, it is the first clinical interventional research whether L-carnitine corrects ammonia metabolism associated with liver injury in hepatectomized patients.

Enrollment

80 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

patients were those surgically treated for hepato-biliary diseases

Exclusion criteria

Patient exclusion criteria included a body weight loss greater than 10% during the six months prior to surgery, the presence of distant metastases, or seriously impaired function of vital organs due to respiratory, renal or heart disease.

Trial design

80 participants in 2 patient groups, including a placebo group

ordinary group
Placebo Comparator group
Description:
usual intake prior to liver surgery
Treatment:
Other: usual intake
carnitine group
Active Comparator group
Description:
treatment with oral L-carnitine, 1500 mg/body per day for 2 weeks prior to liver surgery
Treatment:
Drug: L-carnitine

Trial contacts and locations

0

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Central trial contact

Takehiro Okabayashi, MD

Data sourced from clinicaltrials.gov

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