L-menthol as a Topical Counter-irritant to TRPA1-induced Neurogenic Inflammation and Pain

Aalborg University

Status: Completed

Conditions: Inflammation; Hyperalgesia; Pruritus

Treatments: Other: Vehicle, topical ethanol 96%; Other: Topical L-menthol 40%

Study type: Interventional

Funder types: Other

Identifiers

NCT02653703

N-20130005

Details and patient eligibility

About

The aim of this study is to quantitatively characterize the effects of L-menthol as a topical counter-irritant on cutaneous pain and hyperalgesia provoked by topical application of the TRPA1-agonist trans-cinnamaldehyde (CA) in healthy human volunteers.

Full description

This study is designed as an experimental model in healthy humans.

Enrollment: 14 patients

Sex

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 healthy men and women aged 18-50 years willing to abstain from alcohol, nicotine, caffeine and pain medication 24 hours before experimental sessions

Exclusion criteria

• Pregnancy
• Skin disorders (e.g. contact eczema)
• Chronic pain conditions
• Drug addiction defined as the use of cannabis, opioids or other drugs
• Previous neurologic, musculoskeletal or mental illnesses
• Lack of ability to cooperate

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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14 participants in 2 patient groups, including a placebo group

Vehicle, topical ethanol 96%

Placebo Comparator group

Description:

Exposure: 10 % topical trans-cinnamaldehyde \[CAS Number: 14371-10-9\] Vehicle: 96% ethanol

Treatment:

Other: Vehicle, topical ethanol 96%

Topical L-menthol 40%

Experimental group

Description:

Exposure: 10 % trans-cinnamaldehyde \[CAS Number: 14371-10-9\] Intervention: 40% l-menthol \[CAS Number: 2216-51-5\] Vehicle: 96% ethanol

Treatment:

Other: Topical L-menthol 40%