L-PRF Versus A-PRF on Palatal Wound Healing

Izmir Katip Celebi University

Status: Completed

Conditions: Palate; Wound

Treatments: Procedure: A-PRF; Procedure: Palatal stent; Procedure: L_PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT06242314

1090/2020

Details and patient eligibility

About

Different approaches are used to reduce post-operative complications associated with the palatal wound site after free gingival graft (FGG) harvesting. The aim of this study was to compare the effects of L-PRF and A-PRF on palatal wound healing after free gingival graft harvesting and patients' quality of life.

Full description

Thirty-six patients between the ages of 18 and 60 years (11 males and 25 females) who had completed Phase 1 periodontal treatments and for whom FGG surgery was indicated for isolated gingival recession defects limited to one or two teeth with shallow vestibule and insufficient keratinized or attached gingival width were included in the present study.

Three different treatments were performed on palatal wound areas: L-PRF (L-PRF group, n = 12), A-PRF (A-PRF group, n = 12) and palatal stent (control group, n = 12) OHIP-14 scores, VAS scores (for pain), analgesic tablet intake, and epithelialization condition were recorded for different time points.

Enrollment: 36 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients ≥18 years requiring FGG surgery because of shallow vestibule and insufficient keratinized/attached gingival width

Exclusion criteria

• no smoking /no alcohol use,
• not suffering from any systemic disease that could impair the healing of wounds,
• pregnancy or lactation,
• Previous graft harvesting from the same site.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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36 participants in 3 patient groups, including a placebo group

L-PRF

Experimental group

Description:

L-PRF was laid directly on the palatal wound immediately after free gingival graft harvesting and stabilized with silk suture.

Treatment:

Procedure: L_PRF

A-PRF

Experimental group

Description:

A-PRF was laid directly on the palatal wound immediately after free gingival graft harvesting and stabilized with silk suture.

Treatment:

Procedure: A-PRF

Palatal stent

Placebo Comparator group

Description:

Palatal stent was prepared by taking impression of the palate before surgery. After FGG harvesting, periodontal paste (COE-PAK periodontal dressing, GC, Illinois, USA) was applied on the wound surface of the palatal stent and the palate was closed.

Treatment:

Procedure: Palatal stent