L-PRF vs PBM on Extraction Socket Healing

Akdeniz University

Status: Completed

Conditions: Healing Surgical Wounds; Pain

Treatments: Device: photobiomodulation; Other: Leukocyte and Platelet Rich Fibrin

Study type: Interventional

Funder types: Other

Identifiers

NCT06328413

KAEK-302

Details and patient eligibility

About

The aim of this study is to compare leukocyte and platelet-rich fibrin (L-PRF) and photobiomodulation (PBM) applications, which have been repeatedly reported to be superior to control groups, in terms of pain, soft tissue and bone healing in tooth extraction sockets.

Full description

After sample size calculation, healthy volunteers were included in the study. Both teeth of these individuals with bilaterally impacted wisdom teeth were extracted simultaneously. Photobiomodulation (PBM) or leukocyte and platelet rich fibrin (L-PRF), an autogenous blood product, was randomly applied to the right or left side extraction sockets. Volunteers were called for repeat sessions (days 2,4,7,7,11,11,14,18 and 21) for the PBM treated side. Follow-ups were performed for pain (days 2,4,7) and soft and bone tissue healing.

Enrollment: 34 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) Class-I healthy volunteers
• Between 18 and 40 years of age who had wisdom teeth (Pell and Gregory Class II, Position B) with bone retention in bilateral symmetrical position with an indication for extraction, and had second molars in the mouth,
• Not use steroids or anti-inflammatory drugs in the last 3 months.

Exclusion criteria

• Patients with pericoronitis,
• Smoking habits
• Active periodontal disease
• Pregnancy,
• Breastfeeding
• Unable to give personal consent, and those with missing physical examination and follow-up records were excluded.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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34 participants in 2 patient groups

Photobiomodulation group

Experimental group

Description:

Photobiomodulation application at different extra and intraoral points for 60 seconds with a wavelength of 940 nm in repeated sessions after the extraction of third molar

Treatment:

Device: photobiomodulation

Leukocyte and platelet-rich fibrin group

Active Comparator group

Description:

Leukocyte and platelet rich fibrin ( blood product centrifuged for 12 minutes at 2700rpm) application after third molar extraction, single session.

Treatment:

Other: Leukocyte and Platelet Rich Fibrin